Publication



           Welcome to the Liu Lab

Lee NK, Su Y, Bidlingmaier S, Liu B. Manipulation of cell-type selective antibody internalization by a guide-effector bispecific design. Mol Cancer Ther. 2019 Apr 8. pii: molcanther.1313.2018. doi: 10.1158/1535-7163.MCT-18-1313. [Epub ahead of print] PMID:30962321

Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018 Sep 6;3(17). pii: 121497. doi:10.1172/jci.insight.121497. [Epub ahead of print] PMID:30185663

Lee NK, Zhang Y, Su Y, Bidlingmaier S, Sherbenou DW, Ha KD, Liu B. Cell-type specific potent Wnt signaling blockade by bispecific antibody. Sci Rep. 2018 Jan 15;8(1):766. doi: 10.1038/s41598-017-17539-z. PMID:29335534

Su Y, Bidlingmaier S, Lee NK, Liu B. Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens. Methods Mol Biol. 2018;1701:331-347. doi: 10.1007/978-1-4939-7447-4_18. PMID:29116514

Lee NK, Bidlingmaier S, Su Y, Liu B. Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes. Methods Mol Biol. 2018;1701:61-82. doi: 10.1007/978-1-4939-7447-4_4. PMID:29116500

Ha KD, Bidlingmaier SM, Su Y, Lee NK, Liu B. Identification of Novel Macropinocytosing Human Antibodies by Phage Display and High-Content Analysis. Methods Enzymol. 2017;585:91-110. doi: 10.1016/bs.mie.2016.10.004. Epub 2016 Dec 1. PMID:28109445

Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14. PMID:27841764; PMCID:PMC5127683

Ha KD, Bidlingmaier SM, Liu B. Macropinocytosis Exploitation by Cancers and Cancer Therapeutics. Front Physiol. 2016 Sep 12;7:381. doi: 10.3389/fphys.2016.00381. PMID:27672367

Bidlingmaier S, Ha K, Lee NK, Su Y, Liu B. Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing. Mol Cell Proteomics. 2016 Jan 4. pii: mcp.M115.055954. [Epub ahead of print] PMID: 26729710 

Bidlingmaier S, Su Y, Liu B. Combining Phage and Yeast Cell Surface Antibody Display to Identify Novel Cell Type-Selective Internalizing Human Monoclonal Antibodies. Methods Mol Biol. 2015;1319:51-63. doi: 10.1007/978-1-4939-2748-7_3. PMID: 26060069

Bidlingmaier, S. and Liu, B. Identification of Novel Protein-Ligand Interactions by Exon Microarray Analysis of Yeast Surface Displayed cDNA Library Selection Outputs. Methods Mol Biol. 2015;1319:179-92. doi: 10.1007/978-1-4939-2748-7_9. PMID: 26060075

Bidlingmaier, S. and Liu, B. Identification of Posttranslational Modification-Dependent Protein Interactions Using Yeast Surface Displayed Human Proteome Libraries. Methods Mol Biol. 2015;1319:193-202. doi: 10.1007/978-1-4939-2748-7_10. PMID: 26060076

Bidlingmaier, S. and Liu, B.  Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions. Methods Mol Biol. 2015;1319:203-14. doi: 10.1007/978-1-4939-2748-7_11. PMID: 26060077

Sherbenou, D.W., Behrens, C.R., Su, Y., Wolf, J.L., Martin, T.G. 3rd, Liu, B. The development of potential antibody-based therapies for myeloma.  Blood Rev. 2014 Sep 28. pii: S0268-960X(14)00080-0. doi: 10.1016/j.blre.2014.09.011. [Epub ahead of print]  PMID: 25294123

Ha, K.D., Bidlingmaier, S.M., Zhang, Y., Su, Y., Liu, B. High-content analysis of antibody phage-display library selection outputs identifies tumor selective macropinocytosis-dependent rapidly internalizing antibodies. Mol Cell Proteomics. 2014 Aug 22. pii: mcp.M114.039768. [Epub ahead of print] PMID: 25149096 

Behrens, C.R. and Liu, B. Methods for site-specific drug conjugation to antibodies. MAbs. 2013 Sep 27;6(1). [Epub ahead of print] PMID: 24135651

Federman, N., Chan, J., Nagy, J.O., Landaw, E.M., McCabe, K., Wu, A.M., Triche, T., Kang, H., Liu, B., Marks, J.D., Denny, C.T.  Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor.
Sarcoma, 2012:126906 (2012) PMID: 23024593

McCabe, K.E., Liu B., Marks, J.D., Wu., H., and Wu, A. An engineered cysteine-modified diabody for PET imaging of ALCAM-positive pancreatic and colorectal tumor models. Molecular Imaging Biology, 14(3):336-47 (2012).
PMID: 21630083


Bidlingmaier, S., Wang, Y., Liu, Y., Zhang, N., and Liu, B. Comprehensive analysis of yeast surface cDNA display library selection outputs by exon microarray to identify novel protein-ligand interactions. Mol Cell Proteomics, 10(3):M110.005116 (2011) PMID: 21127146

Bidlingmaier, S. and Liu, B. Construction of yeast surface-displayed cDNA libraries. Methods Mol Biol, 729: 199-210 (2011) PMID: 21365492

Bidlingmaier, S. and Liu, B. Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries. Methods Mol Biol, 729:211-23 (2011)
PMID: 21365493

Iyer, A.K., Su, Y., Feng, J.J., Lan, X., Zhu, X., Liu, Y., Gao, G., Seo, Y., VanBrocklin, H.F., Broaddus, V.C., Liu, B., and He, J. The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma in vivo. Biomaterials. 32(10):2605-13 (2011)
PMID: 21255833

Iyer, A.K., Lan, X., Zhu, X., Su, Y., Feng, J., Zhang, X., Gao, D., Seo, Y., VanBrocklin,, H.F.,  Broaddus, V.C., Liu, B.*, and He, J.* Novel rapidly internalizing human single chain antibody fragment targeting epithelioid and sarcomatoid mesothelioma in vivo. Cancer Res.
71(7):2428-32 (2011) PMID: 21447742

He, J., Wang, Y., Feng, J., Zhu, J., Lan, X., Iyer, A.K., Zhang, N., Seo, Y., VanBrocklin, H.F., and Liu, B
. Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody fragment. J Nucl. Med., 51(3):427-32 (2010). PMCID: PMC2832590

Zhu, X., Bidlingmaier, S., Hashizume, R., James, C.D., Berger, M.S. and Liu, B. Identification of internalizing human single chain antibodies targeting brain tumor sphere cells. Mol Cancer Ther, 9(7):2131-41 (2010).
PMID: 20587664

Chen
, Y., Zhu, X., Zhang, X., Liu, B.*, and Huang, L*. Nanoparticles modified with tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy. Mol Therapy, 18(9):1650-6 (2010). PMID: 20606648

Drummond, D.C., Noble, C.O., Guo, Z., Hayes, M.E., Connoly-Ingrim, C., Gabriele, B., Hann, B., Liu, B., Park, J.W., Hong, K., Benz, C.C., Marks, J.D., Kirpotin, D.B. Development of a highly stable and targetable nanoliposomal formulation of topotecan. J Control Release. 141(1):13-21 (2010)
PMID: 19686789

Conrad, F., Zhu, X., Zhang, X., Chalkley, R.J., Burlingame, A.L., Marks, J.D., and Liu, B. Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion.  J Mol Med, 87(5): 507-14 (2009).
NIHMSID 164984

Bidlingmaier, S., He, J., Wang, Y., An, F., Feng, J., Gao, J., Barbone, D., Franc, B., Broaddus, C.V. and Liu, B. Identification of the antigen bound by a tumor-targeting phage antibody using yeast surface human proteome display:  MCAM is a mesothelioma-associated cell surface antigen.  Cancer Res, 69(4): 1570-77 (2009).
NIHMSID 82311

An, F., Drummond, D.C., Wilson, S., Kirpotin, D.B., Nishimura, S., Broaddus, C.V. and Liu, B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single chain antibodies.  Mol Cancer Ther, 7(3):569-78 (2008).
PMID: 18319332

Bidlingmaier, S., Zhu, X., and Liu, B.  The utility and limitation of CD133 epitopes in defining tumor stem cell population.  J Mol Med, 86(9):1025-32 (2008).
NIHMSID 78090

Liu, B.  Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA. Brief Funct Genomic Proteomic, 6(2):112-9 (2007). PMID: 17670766

Liu, B., Conrad, F., Roth, A., Drummond, D.C., Simko, J., Marks, J.D. Recombinant full-length human IgG1s targeting hormone refractory prostate cancer. J Mol Med, 85(10):1113-23 (2007).
PMID: 17554518

Goenaga, A-L., Zhou, Y., Legay, C., Bougherara, H., Huang, L., Liu, B., Drummond, D.C., Kirpotin, D.B., Auclair, C., Marks, J.D., Poul, M-A.  Characterization of tumor markers combining antibody phage display and intrabody strategies. Mol Immunology, 44(15):3777-3788 (2007). PMID: 17498801


Roth, A., Drummond, D.C., Conrad, F., Hayes, M.E., Kirpotin, D.B., Benz, C.C., Marks, J.D. and Liu, B. Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells. Mol Cancer Ther, 6(10): 2737-46 (2007).
PMID: 17938267

Bidlingmaier, S. and Liu, B.  Interrogating yeast surface displayed human proteome for Identification of small molecule binding proteins. Mol Cell Proteomics, 6(11): 2012-20 (2007).
PMID: 17660511

Bidlingmaier, S. and Liu, B. Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions. Mol Cell Proteomics, 5(3):533-40 (2006).
PMID: 16321969

Ruan, W., Sassoon, A., An, F., Simko, J.P. and Liu, B. Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection. Mol Cell Proteomics, 5(12):2364-73 (2006). PMID: 16982673

Liu, B., Conrad, F., Cooperberg, M.R., Kirpotin, D.B., Marks, J.D. Mapping tumor epitope space by direct selection of single chain Fv antibody libraries on prostate cancer cells. Cancer Res, 64(2):704-710 (2004). PMID: 14744788


Liu, B., Huang, L., Sihlbom, C., Burlingame, A.L., Marks, J.D. Towards proteome-wide production of monoclonal antibody by phage display. J Mol Biol, 315(5):1063-1073 (2002). PMID: 11827476


Liu, B. and Marks, J.D.  Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigen blotted on nitrocellulose. Anal. Biochem, 286(1):119-28 (2000).
PMID: 11038282

Liu, B. and Connolly, M.K.  The pathogenesis of cutaneous fibrosis. Semin Cutan Med Surg, 17(1):3-11 (1998).
PMID: 9512100

Liu, B. and Alberts, B.M.  Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex. Science,  267(5201):1131-7 (1995).
PMID: 7855590

Liu, B., Wong, M.L., Alberts, B.M. A Transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain. Proc. Natl. Acad. Sci. USA, 91(22):10660-4 (1994).
PMID: 7524099

Liu, B., Wong, M.L., Tinker, R.L., Geiduschek, E.P., Alberts, B.M.  The DNA replication fork can pass RNA polymerase without displacing the nascent transcript. Nature, 366(6450):33-9 (1993). PMID: 8232535